Impact on posttraumatic stress in patients undergoing allogeneic hematopoietic stem cell transplantation

Impact on posttraumatic stress in patients undergoing allogeneic hematopoietic stem cell transplantation

Annotated Bibliography

1. Li T, Yang M, Tseng A, Lee H. Pre-habilitation and rehabilitation for surgically treated lung cancer patients. Journal of Cancer Research and Practice. 2017;4(3):89-94. doi:10.1016/j.jcrpr.2017.06.001

The study was conducted in Taiwan where lung cancer was documented to the most common malignancy between 2002 and 2008. There was a significant difference between the 5-year rate of survival for the patient that underwent surgery and those who did not. No sufficient evidence exists to support the functional assessment prior to surgery but exercise capacity assessment is crucial for management of lung cancer patients for prognostic and therapeutic purposes. It may be linked with increases number of inoperable-to-operable cases and decreases cases of perioperative morbidity and mortality. Rehabilitation after surgical procedures improves the performance of patients and quality of life, and it therefore deserves to receive more attention from clinicians.

1. Kuba K, Esser P, Scherwath A et al. Cancer-and-treatment-specific distress and its impact on posttraumatic stress in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Psych oncology. 2016;26(8):1164-1171. doi:10.1002/pon.4295

The study was a prospective multicenter study. It involved the investigation of cancer-and-treatment specific distress and the impacts that it has on the symptoms of post-traumatic stress disorder. This was conducted on patient undergoing allogenic hematopoietic stem cell transplantation. The patients in the study were examined before the study and 12 months after the allogenic stem cell transplant. The information that was collected included demographic data, medical information and assessment of PTSD and CTXD. The factors which were found to be most distressing include family strain, uncertainty and health burden. Women were found to mainly report the destressing factors to be sexuality, uncertainty and appearance. These factors emerged as predictors of PTSD symptomatology.

1. Dittus K, Lakoski S, Savage P et al. Exercise-Based Oncology Rehabilitation. J Cardiopulm Rehabil Prev. 2015;35(2):130-139. doi:10.1097/hcr.0000000000000091

The study examines the value of exercise and rehabilitative interventions for the survivors of cancer. The services are valuable for cancer patients but there is no pathway which has been delineated for these services. The study outlines the rehabilitative needs of cancer survivors and demonstrates the creation of oncology rehabilitation through the use of a CR model. The study found out that cancer survivors have some impairments that are linked to the cancer and the therapy they received, and this can be improved through rehabilitation. The evidence demonstrated that oncology rehabilitation programs lead to the improvement of physiological and psychological parameters among the cancer survivors. Hence, the use of a CR model of rehabilitative services may be crucial for ensuring cancer survivors receive oncology rehabilitation.

1. Tiep B, Sun V, Koczywas M et al. Pulmonary Rehabilitation and Palliative Care for the Lung Cancer Patient. Journal of Hospice & Palliative Nursing. 2015;17(5):462-468. doi:10.1097/njh.0000000000000187

The article examines the role of pulmonary rehabilitation in palliative care for patients of lung cancer. This article considers that the combination of clinical care, behavioral tools, physiological aspects and pulmonary rehabilitation can lead to the rebuilding of the functional capacity of patient who are limited by deconditioning and breathlessness. It documents that exercise is the main tool for the restoration and the endurance of patients by challenging the pathway of oxygen transportation and improving gaseous exchange. The other important tools for pulmonary rehabilitation include bronchodilatation, cessation of smoking, breathing retraining, clearance of airways and oxygen therapy.

1. Michaels C. The importance of exercise in lung cancer treatment. Transl Lung Cancer Res. 2016;5(3):235-238. doi:10.21037/tlcr.2016.03.02

The article considers the emerging evidence which says that exercise may help in the improvement of the condition of people suffering from lung cancer. The article explains that exercise can be beneficial at any stage of lung cancer and it can help in the increment of strength and endurance and well as decreasing of emotional issues. The appropriate programs that is recommended in the article involves breathing, strength training, stretching and aerobic exercises. The provision of these services should be a collaboration between health care providers and the providers of these services.

1. Cuneo KC, Davis MA, Schipper M, Lawrence TS, Feng M. High-serum HGF and low-serum CD40L are associated with liver toxicity after stereotactic body radiation therapy. International Journal of Radiation Oncology• Biology• Physics. 2015 Nov 1;93(3):S114

The study hypothesized that serum cytokine levels could predict radiation induced liver toxicity before the onset of clinical manifestations in patients receiving liver SBRT. The study was conducted as part of a phase two trial. The conclusion of the study was that Serum levels of HGF and CD40L may be early biomarkers of radiation induced liver toxicity from SBRT. The high levels of HGF in serum was previously also found to be elevated in patients suffering from both acute and chronic disease of the liver. The findings of this study could be crucial in the personalization of adaptive radiation therapy for individual patients.

1. Nsouli T, Frandina J, Tanny S, Chaudhari R, Rosenbaum P, Mix MD, Bogart JA, Aridgides PD. Local tumor control after stereotactic body radiation therapy for early lung cancer is not impacted by the use of intensity modulated radiation therapy or respiratory gating. International Journal of Radiation Oncology• Biology• Physics. 2017 Oct 1;99(2):E487.

The paper involves the retrospective review of patients who were treated with SBRT for stage one of non-small cell lung cancer between 2007 and 2015. Patient characteristics, treatment planning and delivery parameters, dosimetry information, and patient outcomes were collected and analyzed using SPSS statistical software. There are several factors which were found not to correlate with local tumor control, and they include the T stage, pathology, SBRT regimen and the size of the tumor. The conclusion of the study was that the utilization of respiratory gating does not appear to compromise the therapeutic ratio for patients treated with SBRT for stage I non-small cell lung carcinoma.

1. D’Journo XB, Falcoz PE, Alifano M, Le Rochais JP, D’Annoville T, Massard G, Regnard JF, Icard P, Marty-Ane C, Trousse D, Doddoli C. Oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate in lung cancer surgery: a randomized clinical trial. Intensive care medicine. 2018 May 1;44(5):578-87.

The paper documents that respiratory complications to be the leading causes of mortality in people who undergo surgery for lung cancer. It hypothesizes that the use of chlorhexidine gluconate for oropharyngeal and nasopharyngeal decontamination would help in the reduction of respiratory complications as it does in cardiac surgeries. The articles entailed a multicenter parallel group randomized double-blind placebo-controlled trial. Th group of patients who received the chlorhexidine gluconate had a decrease level of surgical site infections, Staphylococcus aureus infections and incidence of bacteremia. This indicates that decontamination of the chlorhexidine gluconate post-surgery may reduce the incidence of respiratory infections after lunch cancer surgery.

1. Simone Tramma, MD, MS; Eileen Storey, MD, MPH; David Weissman, MD.“Lung Cancer Screening in the Occupational Setting – An Update.” Centers for Disease Control and Prevention CDC, saving lives, 2012. Retrieved from https://blogs.cdc.gov/niosh-science-blog/2012/08/29/ctscan3/

This article focuses on a study by The National Cancer Institute (NCI) on why lung cancer screening has to be or not be included in the medical occupation setting. It considered several patients who were receiving cancer treatment especially those with a track of current or previous smoking-related issues. NLST was able to establish the potential benefits and harms of LDCT screening in other groups of smokers and other age groups after the completion of the study. An example is that there was the harm of conducting a cancer screening such as diagnostic evaluations of false positive results or cancer from radiation. Hence, the LDCT was able to formulate a modeling balance between the benefits and harms which were as a result of influence from crucial aspects of public health creating guidelines on how to endorse the LDCT lung-cancer screening program.

1. Cerantola Y, Valerio M, Persson B, Jichlinski P, Ljungqvist O, Hubner M, Kassouf W, Muller S, Baldini G, Carli F, Naesheimh T. Guidelines for perioperative care after radical cystectomy for bladder cancer: Enhanced Recovery After Surgery (ERAS®) society recommendations. Clinical nutrition. 2013 Dec 1;32(6):879-87.

Enhanced recovery after surgery (ERAS) pathways were found to significantly reduced complications and length of hospital stay after colorectal procedures. The primary objective was to systematically assess the evidence of ERAS single items and protocols applied to cystectomy patients. it involved the conduction of a systematic literature review on ERAS for cystectomy by searching EMBASE and Medline. The conclusion from the study was that there is need for the development of ERAS protocol of cystectomy. The ERAS may also be formulated for lung cancers to ensure the quick recovery of patients after surgery.

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