Showing all working out, and stating all assumptions, Calculate the total SYSTEMIC CLEARANCE for ‘FCP-17’.

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Coursework Medicine and Health
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Systemic Clearance Extended Calculation
A pharmaceutical company is developing a new drug ‘FCP-17′ and has just determined the following pharmacokinetic parameters from a Phase I human study:
Fraction unbound (fu): 0.5
Clearance by active secretion (CLsec): 2L/hr
Fraction reabsorbed (FR): 0.25
Hepatic Extraction Ratio (EH): 0.25

Question:
Showing all working out, and stating all assumptions, Calculate the total SYSTEMIC CLEARANCE for ‘FCP-17’.

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Inter-Individual Variability
A pharmaceutical company has convinced your paramedic service to add their new orally administered opioid analgesic ‘fucpoaphine’ to their formulary. Fucpoaphine requires hepatic activation in order to elicit an analgesic effect. Studies in healthy volunteers have demonstrated that fucpoaphine is rapidly activated (within 2minutes) following oral administration and that the sole enzyme involved in the activation of fucpoaphine is CYP2C19.

Questions:
a) Select ONE specific factor (environmental, genetic or physiological) that may contribute to inter-individual variability in the activation of fucpoaphine, and explain the potential consequences of this variability in terms of treatment response and tolerability. (200 words)

b) Identify a strategy to account for variability in fucpoaphine activation that can be used in a pre-hospital situation and briefly explain how this strategy could be used to optimise treatment response and tolerability. (100 words)

 

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Explain the scientific and technical concepts related to nuclear medicine

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Explain the scientific and technical concepts related to nuclear medicine
Paper , Order, or Assignment Requirements

• Explain the scientific and technical concepts related to nuclear medicine. Consider the following questions when you construct your response:
o What type of radiation is typically exploited in most nuclear medicine procedures?
o How are patients prepared for nuclear medicine procedures?
o What are the advantages and limitations of nuclear medicine?
o What ailments are typically diagnosed and treated via nuclear medicine procedures?
• Evaluate a minimum of three applications of nuclear medicine relating to any of the following topics:
o Positron Emission Tomography (PET) scans
o Gallium scans
o Indium white blood cell scans
o Iobenguane scans (MIBG)
o Octreotide scans
o Hybrid scanning techniques employing X-ray computed tomography (CT) or magnetic resonance imaging (MRI)
o Nuclear medicine therapy using radiopharmaceuticals
Support your statements with examples. Provide a minimum of three scholarly references.
Write a 2–3-page paper in Word format. Apply APA standards to citation of sources.

 

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) Based on the results, parts a and b, what conclusions can the pediatric researchers draw about which group has the smaller variation in improvement scores?

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The Archives of Pediatrics and Adolescent Medicine (Dec. 2007) cond
Paper , Order, or Assignment Requirements

Project Description:
The Archives of Pediatrics and Adolescent Medicine (Dec. 2007) conducted a study of 105 ill children to determine if honey was a remedy for coughing. The children were randomly divided into groups. One group received a dosage of an over-the-counter cough medicine (DM); another group received a dosage of honey (H). The coughing improvement scores (as determined by the children’s parents) for the patients in the two groups are reproduced in the HONEYCOUGH file. The pediatric researchers desire information on the variation in coughing improvement scores for each of the two groups.

a) Find a 90% confidence interval for the standard deviation in improvement scores for the honey dosage group.

b) Repeat part a for the DM dosage group.

c) Based on the results, parts a and b, what conclusions can the pediatric researchers draw about which group has the smaller variation in improvement scores?

 

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• Explain the process of evidence-based analysis.

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Evidence-based medicine (EBM)
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Evidence-based medicine (EBM), previously translational medicine, can be defined as improving care based on empirical research and/or hands-on practice. The EBM’s approach is based on either direct patient care (bottom-up) or an experiment translated into guidelines (top-down). EBM is used in either in conjunction or as quality assessment tool(s) for continuous quality improvement (CQI). The healthcare leader must utilize the evidence to promote healthcare quality.
• Explain the process of evidence-based analysis.
• Highlight the major players and their roles in EBM policy (i.e., government, providers, patients, etc.).
• Explain the EBM “Levels of Evidence” as defined in your course text.
• Review the case “Constraints of the ACA on Evidence-Based Medicine.”
• Provide a written analysis of the case “Constraints of the ACA on Evidence-Based Medicine” ATTACHMENT INCLUDED(Utilize the “Levels of Evidence and Grades of Recommendations” as defined by the National Guideline) Clearinghouse.
• Summarize the policy of EBM in your conclusion.

 

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Science -research article related to nursing or medicine to critique.

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Science -research article related to nursing or medicine to critique.
Paper , Order, or Assignment Requirements

Research Problem/Purpose State the problem clearly as it is presented in the report. Have the investigators placed the study problem within the context of existing knowledge? Will the study solve a problem relevant to nursing? State the purpose of the research. Review of the Literature Identify the concepts explored in the literature review. Were the references current? If not, what do you think the reasons are? Theoretical Framework Are the theoretical concepts defined and related to the research? Does the research draw solely on nursing theory or does it draw on theory from other disciplines? Is a theoretical framework stated in this research piece? If not, suggest one that might be suitable for the study. Variables/Hypotheses/Questions/Assumptions What are the independent and dependent variables in this study? Are the operational definitions of the variables given? If so, are they concrete and measurable? Is the research question or the hypothesis stated? What is it? Methodology What type of design (quantitative, qualitative, and type) was used in this study? Was inductive or deductive reasoning used in this study? State the sample size and study population, sampling method, and study setting. Did the investigator choose a probability or non-probability sample? State the type of reliability and the validity of the measurement tools. Were ethical considerations addressed? Data Analysis What data analysis tool was used? How were the results presented in the study? Identify at least one (1) finding. Summary/Conclusions, Implications, and Recommendations What are the strengths and limitations of the study? In terms of the findings, can the researcher generalize to other populations? Explain. Evaluate the findings and conclusions as to their significance for nursing. The body of your paper should be 4–6 double-spaced pages plus a cover page and a reference page

 

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Read through the list of research topics (located in the Appendix) on which to write a research paper. Select three (3) topics that interest you most and identify two (2) credible sources for each topic. Note: This is one (1) of several parts that will build toward a final draft of your persuasive writing research paper.

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ssignment 1: Research Topics with Explanation

Due Week 2 and worth 100 points

Read through the list of research topics (located in the Appendix) on which to write a research paper. Select three (3) topics that interest you most and identify two (2) credible sources for each topic. Note: This is one (1) of several parts that will build toward a final draft of your persuasive writing research paper.

Write a one to two (1-2) page paper in which you:

1. Explain the reason for selecting topic one (1), identify the audience, and provide a preliminary thesis statement.

2. Explain the reason for selecting topic two (2), identify the audience, and provide a preliminary thesis statement.

3. Explain the reason for selecting topic three (3), identify the audience, and provide a preliminary thesis statement.

4. Identify and document six (6) credible sources (two (2) for each topic) that you would expect to use. Note: Wikipedia and other Websites do not qualify as academic resources.

Your assignment must follow these formatting guidelines:

 Be typed, double spaced, using Times New Roman font (size 12), with one-inch margins on all sides; references must follow APA or school-specific format. Check with your professor for any additional instructions.

 Include a cover page containing the title of the assignment, the student’s name, the professor’s name, the course title, and the date. The cover page and the reference page are not included in the required page length.

 

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What is a Punnett Square? How can it be used to analyze possible genetic outcomes for offspring? What is dominant/recessive inheritance? What is X-linked inheritance? What is codominant inheritance of genes?

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Type: Individual Project
Unit:  Lab to Determine the Outcome of Heredity
Due Date:  Tue, 1/2/17
Grading Type: Numeric
Points Possible:  200
Points Earned:  0
Deliverable Length:  Completed Lab Worksheet
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Assignment Details

Student Instructions

For each assignment, you will complete the following steps:

  1. Click on Learning Materials to Access the M.U.S.E.
  2. Use the M.U.S.E. link to complete the lab for this Unit.
  3. Track your results in the lab worksheet that is provided.
  4. Complete a lab report using the scientific method.
  5. Submit your completed lab worksheet to the assignment box.

Using the Laws of Inheritance

Gregor Mendel’s studies laid the foundation for modern genetics. In a series of elegant experiments, Mendel was able to deduce the most fundamental laws of single-gene and multiple-gene inheritance without having the scientific data on chromosomes, their structure, or meiotic segregation. In this lab, you will learn about and apply examples for 3 different patterns of human inheritance of traits.

In this lab, you will view information and complete activities to answer the following questions about genes and inheritance:

  • What is a Punnett Square? How can it be used to analyze possible genetic outcomes for offspring?
  • What is dominant/recessive inheritance?
  • What is X-linked inheritance?
  • What is codominant inheritance of genes?

Using the M.U.S.E. link, review the background information and animation to complete your report. Use the lab 3 worksheet for assignment instructions and data collection.

This assignment will also be assessed using additional criteria provided here.

Please submit your completed assignment in your assignment box.

 

Grading Category Category Criteria Percentage and Points Possible
Purpose of Assignment and Content Development Use of appropriate, relevant, and compelling content that expresses topic, main idea, and purpose. 45% (90 of 200 points)
Organization, Grammar, and Presentation Organized and complete lab report/worksheet with all relevant information as indicated and outlined on the worksheet.  Language clearly and effectively communicates ideas and content relevant to the assignment. 30% (60 of 200 points)
Critical Thinking Demonstrates ability to analyze assumptions, evaluate evidence, complexities of issues, and alternatives. 20% (40 of 200 points)
Information Literacy and Research Demonstrates good selection and use of high quality, credible, and relevant sources to develop ideas that are appropriate to the assignment.  Includes correct in-text citations.
 

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Identify the television show or recent movie you watched, and introduce the brand of a consumer product that you found was featured in the plot of the story.

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Goods and Services Marketing

The success of a product or a company in the marketplace is highly dependent on the target markets ability to distinguish a given product from another. One way this is accomplished is through branding. When it comes to branding, companies must make complex decisions that will have a prolonged effect on the perception of the product and company in the marketplace. In this discussion, you will discuss product placements based on brand name marketing in the film industry.

Scenario:

Product placement deals have been a common practice in the film industry for quite some time, but the focus on placing popular brands in movies and television shows was never as important as it is today. To execute this Assignment, watch one of your favorite television shows or a recent popular movie and discover a brand of a product that is featured in the plot of the story. Pay close attention, sometimes it can be tricky to identify a popular brand being featured if your mind is not consciously looking for it.

Directions to complete this Assignment:

  • Read Chapter 10 in your textbook to understand how companies make branding decisions.
  • Download an explanation of marketing uses for branding here.
  • Watch the video segment on the Tom Peters website by going to “Tom’s Topics” under “video” at: www.tompeters.com to view Brand, Design, and Differentiation (Tom Peters Company ©1999-2014) to supplement your understanding of product branding by Tom Peters-Filmed by BVO 2009.

Used by permission of Tom Peters. See www.tompeters.com for additional information.

Checklist: In 250 words or more, answer the following questions:

  1. Identify the television show or recent movie you watched, and introduce the brand of a consumer product that you found was featured in the plot of the story.
  2. Discuss the type of consumer product (convenience, shopping, specialty, unsought) you identified in the plot of the story. Explain your answer.
  3. Discuss how the television show or movie increases or decreases the brand equity of the product.
  4. Describe the brand strategy of the product you identified within the plot of the story.

Directions for Submitting this Assignment:

 

Review the grading rubric below before beginning this activity. Respond in a Microsoft Word document in a minimum of 250 words to the checklist items above using APA format and citation style. Make sure to include an additional Title and references page.

For additional help with your writing and APA citation, please visit the Kaplan University Writing Center accessed from the home area of this course. Save your Assignment titled per the example (Ex: TAllen-MT219 Assignment-Unit 7.docx) and submit your file by selecting the Unit 7: Assignment Dropbox by the end of Unit 7.

 

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Describe cognitive social phenomena that occur specifically to the context of the MMORPG that wouldn’t happen in a face-to-face checkers game. 

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In a virtual world (VW) of massively multiplayer online role-playing games (MMORPGs), collaboration and communication are provided through the Internet between MMORPG-ready devices such as the Microsoft Xbox, and Sony PlayStation, and by using the Web browser. Gamers around the world can play against other gamers without seeing their opponent face-to-face. The Internet and MMORPG devices have become a social phenomenon. For example, a mobile game, called “Game of War” enables players to play against each other anywhere around the world.

The following Website might be helpful when writing this assignment:

Write a four to five (4-5) page paper in which you:

  1. Describe cognitive social phenomena that occur specifically to the context of the MMORPG that wouldn’t happen in a face-to-face checkers game.
  2. Compare and contrast the MMORPG user interaction environment and a face-to-face environment where Spades is being played. Next, identify whether or not the environment has an impact on the player’s ability to play Spades in this environment.
  3. Outline and describe the user interface requirements that a game designer needs to include in order to engage players in a MMORPG environment.
  4. Use at least three (3) quality resources in this assignment. Note: Wikipedia and similar Websites do not qualify as quality resources.
  5. Format your assignment according to the following formatting requirements:
    1. Typed, double spaced, using Times New Roman font (size 12), with one-inch margins on all sides.
    2. Include a cover page containing the title of the assignment, the student’s name, the professor’s name, the course title, and the date. The cover page is not included in the required page length.
    3. Include a reference page. Citations and references must follow APA format. The reference page is not included in the required page length.

The specific course learning outcomes associated with this assignment are:

  • Compare and contrast the various cognitive models.
  • Construct evaluation techniques to the user experience and system usability in the design process.
  • Describe the differences in developing user interfaces for different application environments.
  • List the general principles used in the heuristic evaluation of a user interface design.
  • Use technology and information resources to research issues in human-computer interaction.
  • Write clearly and concisely about human-computer interaction topics using proper writing mechanics and technical style convention
 

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