What is the key structural question which is discussed in this chapter and why is this question important?

Order Details/Description

Taxation Assessment 1

A report on the reform of UK taxation was commissioned by the Institute for Fiscal Studies (IFS). The report was written by leading public finance economists, led by a Nobel Prize-winning Cambridge professor James Mirrlees. The report, published in 2012, takes a broad view of taxation taking into account the vast research which has been done in the area of public finance and taxation..

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Small Business Taxation by Claire Crawford and Judith Freedman forms Chapter 11of this report. This chapter deals with aspects of individual taxation which are readily apparent to tax practitioners.

For the purposes of this assessment you are required to read this chapter and answer the following questions:

What is the key structural question which is discussed in this chapter and why is this question important? 20 marks
Proposed maximum word count 700 words.

What approaches have been tried or proposed to address the tax implications of the differential tax treatment. 30 marks
Proposed maximum word count 800 words.

Assuming profits/income of £25,000 and £75,000 update Tables 11C.1 and 11C.2 using 2014-15 tax and NIC rates and discuss the implications of the historical trends for individuals who are employed or self- 20 marks
Proposed maximum word count 700 words.

In your opinion, is there a need to address the differential tax treatment referred to in this chapter. . 20 marks
Proposed maximum word count 700 words.

Presentation and format 10 marks

Maximum word count 2900 words

Total marks 100


Please write each question before answering it.
Each question should start on a new page.
Include all your references at the end of the assignment.
There is no requirement for an introduction or contents page.
Use Harvard (author-date) style referencing.
References and questions’ word count is excluded from total 2900 word count.
You will need to submit a hard copy via the assignment office and an electronic copy via turn-it-in.

Topic: Molecular Medicine

Category: Chemistry

Order Instructions:

A power point Presentation on a selected Disease using the following instructions:

Do a search on the drug. Find out other names for it. Answer the questions below.
Find out the target of the drug. Is the target expressed in many parts of the body?
How does the drug interact with its target. Is the effect inhibitory or stimulatory, is it complete or partial?
What is the structure of the drug – is it a chemical or a protein. Provide a diagram showing the structure of the drug and if available, show how the drug interacts with its target.
What animal model or models were used to test the efficacy of the drug, in pre-clinical trials? What proteins or family of proteins were shown to be affected in pre-clinical trials?
Is the drug used to treat other diseases that are not related to the brain?
What is the treatment regime for the patient i.e. the mode of delivery to the patient.
What are the side-effects and how are they related to the molecular mechanisms that underly the drug’s efficacy.

For presentation, marks will be allocated as indicated below

Title and outline (1-2 slides)
Brief summary of disease being treated by nominated drug (1-2 slides) -> 10 marks
Description of the drug – its history, structure, properties, target, how it interacts with the target. (2-4 slides) -> 20 marks
Animal models used to test drug (1-2 slides) -> 5 marks
Signalling pathways impacted by drug treatment (1-2 slides) -> 5 marks
Sites of expression of drug target and implication – possible link to reported side-effects (1 slide)-> 5 marks
Summary/conclusions (1-2 slides) -> 5 marks


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